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Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective

Di Cheng, Chunyan Hu, Rui Du, Hongyan Qi, Lin Lin, Xueyan Wu, Lina Ma, Kui Peng, Mian Li, Min Xu, Yu Xu, Yufang Bi, Weiqing Wang, Yuhong Chen, Jieli Lu

《医学前沿（英文）》 2020年 第14卷 第6期   页码 802-810 doi: 10.1007/s11684-019-0723-7

摘要： The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown. This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai, China. Oral glucose tolerance test was conducted during baseline and follow-up visits. Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk. A total of 613 (10.3%) incident diabetes cases were identified during the follow-up visit after 4.5 years. Fasting plasma glucose, postload glucose, and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid (all s<0.05). The incidence rate of diabetes increased across the quartiles of serum uric acid (7.43%, 8.77%, 11.47%, and 13.43%). Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid (odds ratio (95% confidence interval) = 1.36 (1.06−1.73)). Stratified analysis indicated that the association was only observed in women. Accordingly, serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women.

关键词： incident diabetes     prospective study     uric acid    

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Impact of diabetes and its treatments on skeletal diseases

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《医学前沿（英文）》 2013年 第7卷 第1期   页码 81-90 doi: 10.1007/s11684-013-0243-9

摘要：

Diabetes mellitus is an enormous menace to public health globally. This chronic disease of metabolism will adversely affect the skeleton if not controlled. Both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are associated with an increased risk of osteoporosis and fragility fractures. Bone mineral density is reduced in T1DM, whereas patients with T2DM have normal or slightly higher bone density, suggesting impaired bone quality is involved. Detrimental effects of T1DM on the skeleton are more severe than T2DM, probably because of the lack of osteo-anabolic effects of insulin and other pancreatic hormones. In both T1DM and T2DM, low bone quality could be caused by various means, including but not limited to hyperglycemia, accumulation of advanced glycosylation end products (AGEs), decreased serum levels of osteocalcin and parathyroid hormone. Risk for osteoarthritis is also elevated in diabetic population. How diabetes accelerates the deterioration of cartilage remains largely unknown. Hyperglycemia and glucose derived AGEs could contribute to the development of osteoarthritis. Moreover, it is recognized that oral antidiabetic medicines affect bone metabolism and turnover as well. Insulin is shown to have anabolic effects on bone and hyperinsulinemia may help to explain the slightly higher bone density in patients with T2DM. Thiazolidinediones can promote bone loss and osteoporotic fractures by suppressing osteoblastogenesis and enhancing osteoclastogenesis. Metformin favors bone formation by stimulating osteoblast differentiation and protecting them against diabetic conditions such as hyperglycemia. Better knowledge of how diabetic conditions and its treatments influence skeletal tissues is in great need in view of the growing and aging population of patients with diabetes mellitus.

关键词： diabetes     bone     osteoporosis     osteoarthritis    

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New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

《医学前沿（英文）》 2022年 第16卷 第1期   页码 17-24 doi: 10.1007/s11684-021-0873-2

摘要： Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threatening human health. However, no perfect drug choice for obesity exists. Semaglutide is a kind of human glucagon-like peptide-1 (GLP-1) analog that promotes insulin secretion while inhibiting glucagon secretion through a glucose concentration-dependent mechanism. GLP-1 can also delay stomach emptying and suppress appetite to help lose weight. This review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishes expectations on future clinical trials for obesity treatment.

关键词： semaglutide     type 2 diabetes     obesity    

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On subsurface box-shaped lined tunnel under incident SH-wave propagation

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 948-960 doi: 10.1007/s11709-021-0740-x

摘要： In this paper, a half-plane time-domain boundary element method is applied to obtain the seismic ground response, including a subsurface box-shaped lined tunnel deployed in a linear homogenous elastic medium exposed to obliquely incident SH-waves. Only the boundary around the tunnel is required to be discretized. To prepare an appropriate model by quadratic elements, a double-node procedure is used to receive dual boundary fields at corners as well as change the direction of the normal vector. After encoding the method in a previously confirmed computer program, a numerical study is carried out to sensitize some effective parameters, including frequency content and incident wave angle for obtaining a surface response. The depth and impedance ratio of the lining are assumed to be unvaried. The responses are illustrated in the time and frequency domains as two/three-dimensional graphs. The results showed that subsurface openings with sharp corners distorted the propagation path of the anti-plane waves to achieve the critical states on the ground surface. The present approach can be proposed to civil engineers for preparing simple underground box-shaped models with angular boundaries.

关键词： box-lined tunnel     half-plane BEM     surface response     SH-wave     time-domain    

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Early-onset diabetes: an epidemic in China

Jiemin Pan, Weiping Jia

《医学前沿（英文）》 2018年 第12卷 第6期   页码 624-633 doi: 10.1007/s11684-018-0669-1

摘要：

Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man’s sedentary lifestyle, low-physical activity, obesity, and some non-modifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at higher risk of developing vascular complications than those with late-onset diabetes. Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health, which results in poor glycemic control and the delayed detection of diabetes-related complications. Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2 diabetes. Therefore, focusing on this particular population is critical for the government and academic societies. Screening for T2DM is imminent for young adults with a family history of diabetes, obesity, markers of insulin resistance, or alcohol consumption. More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes.

关键词： diabetes     early-onset     diabetes complications    

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Soil seismic analysis for 2D oblique incident waves using exact free-field responses by frequency-based

《结构与土木工程前沿（英文）》 2022年 第16卷 第12期   页码 1530-1551 doi: 10.1007/s11709-022-0900-7

摘要： The seismic analysis of a viscoelastic half-space under two-dimensional (2D) oblique incident waves is carried out by the finite/infinite element method (FIEM). First, the frequency-domain exact solutions for the displacements and stresses of the free field are derived in general form for arbitrary incident P and SV waves. With the present formulation, no distinction needs to be made for SV waves with over-critical incident angles that make the reflected P waves disappear, while no critical angle exists for P waves. Next, the equivalent seismic forces of the earthquake (Taft Earthquake 1952) imposed on the near-field boundary are generated by combining the solutions for unit ground accelerations with the earthquake spectrum. Based on the asymmetric finite/infinite element model, the frequency-domain motion equations for seismic analysis are presented with the key parameters selected. The results obtained in frequency and time domain are verified against those of Wolf’s, Luco and de Barros’ and for inversely computed ground motions. The parametric study indicated that distinct phase difference exists between the horizontal and vertical responses for SV waves with over-critical incident angles, but not for under-critical incident angles. Other observations were also made for the numerical results inside the text.

关键词： oblique incident waves     critical angle     half-space     finite/infinite element approach     seismic response analysis    

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Metabolomics in human type 2 diabetes research

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 4-13 doi: 10.1007/s11684-013-0248-4

摘要：

The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.

关键词： metabolomics     type 2 diabetes     metabolic pathway     mass spectrometry     nuclear magnetic resonance (NMR)    

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Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population

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《医学前沿（英文）》 2017年 第11卷 第1期   页码 110-119 doi: 10.1007/s11684-016-0484-5

摘要：

This study aims to investigate the link between glycated hemoglobin and diabetic complications with chronic periodontitis. A total of 207 patients with type 2 diabetes and chronic periodontitis (CP) were divided according to tertiles of mean PISA (periodontal inflamed surface area) scores as low, middle and high PISA groups. Simultaneously a group of 67 periodontally healthy individuals (PH) was recruited. Periodontal examinations, including full-mouth assessment of probing depths (PPD), bleeding on probing, clinical attachment level and plaque scores were determined. Blood analyses were carried out for glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), 2 h post parandial glucose (PPG). Individuals in PH group had significantly better glycemic control than CP group. Upon one-way analysis of variance, subjects with increased PISA had significantly higher HbA1c levels, retinopathy and nephropathy (P<0.05). After controlling for age, gender, body mass index (BMI), socioeconomic status (SES), family history of diabetes and periodontitis, duration of diabetes, the mean PISA in mm2, PPD 4--6 mm (%) and PPD≥7 mm (%) emerged as significant predictors for elevated HbA1c in regression model (P<0.05). Logistic regression analysis revealed that PISA was associated with higher risk of having retinopathy and neuropathy (odds ratio). In our study, the association between glycemic control and diabetic complications with periodontitis was observed.

关键词： type 2 diabetes mellitus     hemoglobin A     glycated     chronic periodontitis    

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A case of thymic Langerhans cell histiocytosis with diabetes insipidus as the first presentation

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 143-146 doi: 10.1007/s11684-013-0238-6

摘要：

Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. LCH rarely involves the thymus. We report a case of thymic LCH with diabetes insipidus as the first presentation, without evidence of myasthenia gravis and without evidenced involvement of the skin, liver, spleen, bones, lungs and superficial lymph nodes. This present case may have important clinical implications. In screening for LCH lesions, attention should be attached to rarely involved sites in addition to commonly involved organs. Follow-up and imageological examination are very important to a final diagnosis.

关键词： diabetes insipidus     thymus     Langerhans cell histiocytosis    

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Emergency drinking water treatment in source water pollution incident-technology and practice in China

Xiaojian ZHANG , Chao CHEN ,

《环境科学与工程前沿（英文）》 2009年 第3卷 第3期   页码 364-368 doi: 10.1007/s11783-009-0027-2

摘要： An investigation into emergency potable water treatment technologies was conducted to investigate China’s water pollution situation. In order to confirm optimum parameters, the technological efficiency of each pollutant was obtained. About 100 contaminants were tested to find the emergency treatment technologies, most of which were found to be positive. This paper presents the three largest and most significant water pollution incidents in China to date, analyzing cases such as the nitrobenzene pollution incident in the Songhua River in November 2005, the cadmium pollution incident in the Beijiang River in December 2005, and the water crisis with odorous tap water in Wuxi City in May 2007.

关键词： emergency drinking water treatment     water pollution     adsorption     oxidation     precipitation    

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Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai

《医学前沿（英文）》 2022年 第16卷 第1期   页码 126-138 doi: 10.1007/s11684-021-0897-7

摘要： This cross-sectional study aimed to investigate the quality of care of diabetes in Shanghai, China. A total of 173 235 patients with type 2 diabetes in 2017 were included in the analysis. Profiles of risk factors and intermediate outcomes were determined. The patients had a mean age of 66.43±8.12 (standard deviation (SD)) years and a mean diabetes duration of 7.95±5.53 (SD) years. The percentage of patients who achieved the target level for HbA1c (<7.0%) was 48.6%. Patients who achieved the target levels for blood pressure (BP)<130/80 mmHg and low-density lipoprotein-cholesterol (LDL-c)<2.6 mmol/L reached 17.5% and 34.0%, respectively. A total of 3.8% achieved all three target levels, and the value increased to 6.8% with an adaptation of the BP target level (<140/90 mmHg) for those over 65 years. Multivariable analysis identified the factors associated with a great likelihood of achieving all three target levels: male, young age, short diabetes duration, low body mass index, macrovascular complications, no microvascular complications, prescribed with lipid-lowering medication, and no prescription of antihypertensive medication. In conclusion, nearly 50% and one-third of the patients with diabetes met the target levels for HbA1c and LDL-c, respectively, with a low percentage achieving the BP target level. The percentage of patients who achieved all three target levels needs significant improvement.

关键词： type 2 diabetes     quality of care     macrovascular complication     microvascular complication     treatment pattern     epidemiology    

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Oxidative stress and diabetes: antioxidative strategies

Pengju Zhang, Tao Li, Xingyun Wu, Edouard C. Nice, Canhua Huang, Yuanyuan Zhang

《医学前沿（英文）》 2020年 第14卷 第5期   页码 583-600 doi: 10.1007/s11684-019-0729-1

摘要： Diabetes mellitus is one of the major public health problems worldwide. Considerable recent evidence suggests that the cellular reduction–oxidation (redox) imbalance leads to oxidative stress and subsequent occurrence and development of diabetes and related complications by regulating certain signaling pathways involved in β-cell dysfunction and insulin resistance. Reactive oxide species (ROS) can also directly oxidize certain proteins (defined as redox modification) involved in the diabetes process. There are a number of potential problems in the clinical application of antioxidant therapies including poor solubility, storage instability and non-selectivity of antioxidants. Novel antioxidant delivery systems may overcome pharmacokinetic and stability problem and improve the selectivity of scavenging ROS. We have therefore focused on the role of oxidative stress and antioxidative therapies in the pathogenesis of diabetes mellitus. Precise therapeutic interventions against ROS and downstream targets are now possible and provide important new insights into the treatment of diabetes.

关键词： diabetes     oxidative stress     redox modification     antioxidative therapy     novel antioxidant delivery    

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Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

null

《医学前沿（英文）》 2011年 第5卷 第1期   页码 94-100 doi: 10.1007/s11684-011-0116-z

摘要：

Mesenchymal stem cells (MSC) have been used in clinical trials for severe diabetes, a chronic disease with high morbidity and mortality. Bone marrow is the traditional source of human MSC, but human term placenta appears to be an alternative and more readily available source. Here, the therapeutic effect of human placenta-derived MSC (PD-MSC) was studied in type 2 diabetes patients with longer duration, islet cell dysfunction, high insulin doses as well as poor glycemic control in order to evaluate the safety, efficacy and feasibility of PD-MSC treatment in type 2 diabetes (T2D). Ten patients with T2D received three intravenous infusions of PDSC, with one month interval of infusion. The total number of PDSC for each patient was (1.22–1.51) × 106/kg, with an average of 1.35 × 106/kg. All of the patients were followed up after therapy for at least 3 months. A daily mean dose of insulin used in 10 patients was decreased from 63.7?±?18.7 to 34.7?±?13.4 IU (P<0.01), and the C-peptide level was increased from 4.1?±?3.7 ng/mL to 5.6?±?3.8 ng/mL (P<0.05) respectively after therapy. In 4 of 10 responders their insulin doses reduced more than 50% after infusion. The mean levels of insulin and C-peptide at each time point in a total of 10 patients was higher after treatment (P<0.05). No fever, chills, liver damage and other side effects were reported. The renal function and cardiac function were improved after infusion. The results obtained from this pilot clinical trial indicate that transplantation of PD-MSC represents a simple, safe and effective therapeutic approach for T2D patients with islet cell dysfunction. Further large-scale, randomized and well-controlled clinical studies will be required to substantiate these observations.

关键词： placenta stem cells     treatment of type 2 diabetes    

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Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Yu Liao, Yufei Xiang, Zhiguang Zhou

《医学前沿（英文）》 2012年 第6卷 第3期   页码 243-247 doi: 10.1007/s11684-012-0201-y

摘要： Diabetes has become a major public health problem in China nowadays. There are almost 97 million diabetic patients nationwide. Latent autoimmune diabetes in adults (LADA) is a subtype of autoimmune diabetes. Although it has been reported for about 20 years, the diagnostic criteria of this disease remain controversial. The discussion mainly focused on serum autoantibodies, period of insulin need and age of diagnosis. Besides, β cell function, metabolic parameters, genetic factors and cell immunity may also contribute to the formulation of the criteria. Here, we aim to review and discuss the diagnostic criteria of latent autoimmune diabetes in adults.

关键词： LADA     diagnostic criteria     autoantibodies     insulin independence     age of diagnosis    

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Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis

《医学前沿（英文）》 2022年 第16卷 第3期   页码 496-506 doi: 10.1007/s11684-021-0828-7

摘要： The fracture risk of patients with diabetes is higher than those of patients without diabetes due to hyperglycemia, usage of diabetes drugs, changes in insulin levels, and excretion, and this risk begins as early as adolescence. Many factors including demographic data (such as age, height, weight, and gender), medical history (such as smoking, drinking, and menopause), and examination (such as bone mineral density, blood routine, and urine routine) may be related to bone metabolism in patients with diabetes. However, most of the existing methods are qualitative assessments and do not consider the interactions of the physiological factors of humans. In addition, the fracture risk of patients with diabetes and osteoporosis has not been further studied previously. In this paper, a hybrid model combining XGBoost with deep neural network is used to predict the fracture risk of patients with diabetes and osteoporosis, and investigate the effect of patients’ physiological factors on fracture risk. A total of 147 raw input features are considered in our model. The presented model is compared with several benchmarks based on various metrics to prove its effectiveness. Moreover, the top 18 influencing factors of fracture risks of patients with diabetes are determined.

关键词： XGBoost     deep neural network     healthcare     risk prediction    

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标题 作者 时间 类型 操作

Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective

Di Cheng, Chunyan Hu, Rui Du, Hongyan Qi, Lin Lin, Xueyan Wu, Lina Ma, Kui Peng, Mian Li, Min Xu, Yu Xu, Yufang Bi, Weiqing Wang, Yuhong Chen, Jieli Lu

期刊论文

Impact of diabetes and its treatments on skeletal diseases

null

期刊论文

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

期刊论文

On subsurface box-shaped lined tunnel under incident SH-wave propagation

期刊论文

Early-onset diabetes: an epidemic in China

Jiemin Pan, Weiping Jia

期刊论文

Soil seismic analysis for 2D oblique incident waves using exact free-field responses by frequency-based

期刊论文

Metabolomics in human type 2 diabetes research

null

期刊论文

Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population

null

期刊论文

A case of thymic Langerhans cell histiocytosis with diabetes insipidus as the first presentation

null

期刊论文

Emergency drinking water treatment in source water pollution incident-technology and practice in China

Xiaojian ZHANG , Chao CHEN ,

期刊论文

Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai

期刊论文

Oxidative stress and diabetes: antioxidative strategies

Pengju Zhang, Tao Li, Xingyun Wu, Edouard C. Nice, Canhua Huang, Yuanyuan Zhang

期刊论文

Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

null

期刊论文

Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Yu Liao, Yufei Xiang, Zhiguang Zhou

期刊论文

Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis

期刊论文